2022 6th International Conference on Computer, Software and Modeling will be held in Rome, Italy, July 21-23, 2022. ICCSM has a proven track record of success with the first conference held in Male in 2017, the second one in Nice in 2018, the third one in Barcelona in 2019, both the fourth and the fifth one as a virtual conference in 2020 and 2021 subsequently. This year, the conference is co-sponsored by University of the Basque Country and University of Bari. It aims to provide a forum for researchers, practitioners, and professionals from the industry, academia and government to discourse on research and development, professional practice in computer, software and modeling.