The 34th Biennial Dermatology Symposium: The O’Leary Meeting 2025 aims to provide an update on dermatological conditions, new therapeutics, and devices for the dermatologist and dermatological team. The 2025 meeting highlights dermatology crossing paths with other disciplines such as oncology, rheumatology, gastroenterology, surgery, and cosmetics. This symposium consists of a multimedia approach to updating physicians about the current and future care of dermatology patients with both common and rare diseases. Traditional lecture format and interactive panel formats with faculty representation from all three Mayo Clinic sites are used. The information presented is relevant to dermatopathologists, surgical dermatologists, general dermatologists, and pediatric dermatologists.