The 16th ACM/IEEE International Conference on Cyber-Physical Systems (ICCPS) is set to convene in Irvine, California, USA, from May 6-9, 2025 as part of the CPS-IoT Week 2025.

Cyber-physical systems (CPS) are societal-scale engineered systems that are built from, and depend upon, the seamless, correct and safe integration of physical processes, computation components, and in most cases also human supervisors. As a multidisciplinary field, CPS engineering requires theoretical analysis, advanced heuristics, artificial intelligence, security methodologies and big data to work seamlessly together. The deployment of CPS is profoundly transforming how we interact with the physical world, just as the world wide web transformed how we interact with one another. Impact of CPS science is visible across a number of challenging domains including autonomous systems, agriculture, aeronautics, building design, civil infrastructure, energy, environmental quality, healthcare and personalized medicine, manufacturing, and transportation. Further integration and innovations in CPS will continue to have an enormous societal and economic impact.